Neuriva Plus Review 2025 – Does it Work? Is it Safe?

At YLabs, we aim to give you an unbiased opinion of different brain supplements to determine if they are effective and safe based on our research of information about these supplements on the web.

Here we have our Neuriva Plus review. Y-LABS will inspect the information on this brain performance supplement. Seeing how it compares to the other popular products in its category when it comes to supporting your cognitive wellness.

About Neuriva

Neuriva Plus is made by Schiff Vitamins, a well-known supplement company founded in 1936. There are three main versions of the brain supplement Neuriva currently available – Neuriva Original, Neuriva Plus, and Neuriva Ultra. In this review, we’ll focus on Neuriva Plus.

Containing 30 capsules per bottle, Neuriva Plus is claimed to support 6 indicators of brain health:

• Focus
• Memory
• Learning
• Accuracy
• Concentration
• Reasoning

The question is, how will Neuriva Plus work for you? Read on to find out our complete analysis.

Formula Analysis

Neuriva Plus contains these ingredients:

• Vitamin B6 (1.7mg)
• Folate (680mcg DFE) (400mg folic acid)
• Vitamin B12 (cyanocobalamin) (2.4mcg)
• Coffee Fruit Extract (200mg)
• Phosphatidylserine (100mg)

One upside to Neuriva Plus is that it’s completely transparent, free of proprietary blends. This means you can see the dose of each ingredient on the label.

Let’s take a closer look.

Vitamin B6 (1.7mg)

Vitamin B6 is an essential nutrient for the body and mind. Found in eggs, cheese, whole grains and other foods, it’s been shown to help with PMS, memory and brain function and other areas of health.

However, while having many small benefits for the body, vitamin B6 doesn’t appear to have a significant effect unless you’re deficient in it. In other words, vitamin B6 supplementation might not be necessary for most of us. [1]

Folate (680mg DFE) (400mg folic acid)

Folate or vitamin B9 helps regulate homocysteine metabolism. Homocysteine is an amino acid, and a byproduct of foods such as red meat.

While it’s normal to have some homocysteine in your body, having too much has been shown to irritate the cardiovascular system – leading to a build-up of protein plaque which clogs blood vessels. [2]

While this is good news for those looking to support their cardiovascular health, it doesn’t mean much for those looking specifically for nootropic benefits.

Vitamin B12 (cyanocobalamin) (2.4mcg)

Vitamin B12 plays a fundamental role in countless processes in your body. From aiding red blood cell production to assisting the body in creating energy, supplementation can be of particular benefit if you’re deficient in this nutrient.

Usually, healthy people who eat a normal, varied diet aren’t deficient. However, if you’re on a strict plant-based diet, or are elderly, then you could be since vitamin B12 is only naturally found in animal products and its levels might go down as we age.

Coffee Fruit Extract (200mg)

Coffee cherry contains compounds that are suggested to increase levels of a vital brain protein BDNF, which stimulates brain cell growth. Having higher BDNF levels sounds great, especially considering that our levels of this crucial ‘brain growth hormone’ go down as we age.

But does science agree with Neuriva Plus’ claims? A study that is referenced for these claims showed that whole coffee concentrate can boost BDNF. [3] Notice the highlighted words here – it’s whole coffee concentrate, not coffee fruit extract.

Whole coffee concentrate implies there’s a spectrum of compounds from the whole coffee fruit plant. On the other hand, coffee fruit extract is a single compound from the plant.

This ingredient in Neuriva might indeed work, or it might not at all—the jury is still out.

Phosphatidylserine (100mg)

Phosphatidylserine (PS) is a so-called phospholipid compound. It’s a fat found in high amounts in your brain.

As it’s specifically mostly found in the inner part of your brain cell membranes, PS governs many of your brain cell functions. Such as fluidity, permeability, and communication from one brain cell to another. [4]

When a brain cell grows old and is ready to die, PS moves from inside of your brain cell membrane to the outer layer of the membrane.

This signals to your immune system to attack the dying neuron and dispose it quickly. PS also helps protect other brain cells from the collateral damage caused by diseased or dying brain cells.

You may not feel Phosphatidylserine at all. It’s more of a long-term brain health ingredient. It promotes healthy cell structure and communication. It is beneficial for older adults who’re looking to keep their brain sharp as they age.

Our Commentary on Neuriva Plus Ingredients

It looks like Neuriva Plus’ makers have decided to include only a handful of very basic ingredients in the formula.

B vitamins may not do much for you unless you’re deficient in them.

Apart from B vitamins, the only ingredients left in Neuriva Plus are Phosphatidylserine and Coffee Fruit Extract.

This all feels underwhelming when compared to more comprehensive nootropic formulas.

How to Use Neuriva Plus (Directions)

Neuriva Plus dosage instructions are to take 1 capsule daily at bedtime.

The reason why Neuriva Plus is taken at bedtime is because of its reported effects on the Brain-Derived Neurotrophic Factor (BDNF). BDNF levels increase when you sleep.

Related: Prevagen vs Neuriva

Side Effects?

There is always a chance of side effects with supplements, and Neuriva is no exception. Some people report minor headaches and digestive upset. More serious side effects are, though possible, rarely reported.

Don’t take a risk if you have or suspect a health condition. Before taking any supplement, talk to your doctor.

Cost & Where to Buy?

Neuriva Plus can be bought in numerous physical and online stores, including Amazon, Walgreens, Walmart and the official Schiff Vitamins website.

It costs around $40-49 for a bottle of 30 capsules.

Neuriva Plus Review Conclusion

Do we recommend this brain performance supplement? While Phosphatidylserine might produce noticeable benefits for some people, we don’t recommend Neuriva Plus as the best supplement. Other nootropic formulas on the market combine PS with additional well-studied ingredients, possibly leading to greater cognitive benefits.

What do we recommend?

– Click to See The Current Top 3 Highest-Rated Brain Supplements –

References

1. Vitamin B6 – Examine.com.
2. Di Minno MN, Tremoli E, Coppola A, Lupoli R, Di Minno G. Homocysteine and arterial thrombosis: Challenge and opportunity. Thromb Haemost. 2010;103(5):942-961. doi:10.1160/TH09-06-0393
3. Reyes-Izquierdo T, Nemzer B, Shu C, et al. Modulatory effect of coffee fruit extract on plasma levels of brain-derived neurotrophic factor in healthy subjects. Br J Nutr. 2013;110(3):420-425. doi:10.1017/S0007114512005338
4. Glade MJ, Smith K. Phosphatidylserine and the human brain. Nutrition. 2015;31(6):781-786. doi:10.1016/j.nut.2014.10.014

Related:

• Neuriva vs Neuriva Plus
• Neuriva Ultra Review